Reducing affinity as a strategy:
-
Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102553-563 (2000).
-
Viant, C. et al. Antibody affinity shapes the choice between the fate of memory B cells and the germinal center. Cell 1831298–1311.e11 (2020).
-
Forthal, DN Antibody functions. Microbiol. Spectrum. 21–17 (2014).
Google Scholar
-
Singh, S. et al. Monoclonal antibodies: a review. Fluent. Clin. Pharmacol. 1385–99 (2018).
Google Scholar
-
Mullard, A. FDA approves 100th monoclonal antibody product. Nat. Rev. Drug Discov. 20491–495 (2021).
-
Kohler, G. & Milstein, C. Continuous cultures of fused cells secreting an antibody of predefined specificity. Nature 256495–497 (1975).
-
Clackson, T., Hoogenboom, HR, Griffiths, AD & Winter, G. Manufacture of antibody fragments using phage display libraries. Nature 352624–628 (1991).
-
Pedrioli, A. & Oxenius, A. Single B cell technologies for monoclonal antibody discovery. Immunol Trends. 421143-1158 (2021).
-
Mayes, PA, Hance, KW & Hoos, A. The promise and challenges of immune agonist antibody development in cancer. Nat. Rev. Drug Discov. 17509–527 (2018).
-
White, AL et al. The interaction with FcγRIIB is critical for the agonist activity of the anti-CD40 monoclonal antibody. J. Immunol. 1871754-1763 (2011).
-
Yu, X et al. The complex interplay between epitope specificity and isotype dictates the biological activity of human anti-CD40 antibodies. cancer cell 33664–675.e4 (2018).
-
White, AL et al. The hinge conformation of human immunoglobulin G2 confers superagonist properties to immunostimulatory cancer antibodies. cancer cell 27138-148 (2015).
-
Ahonen, C. et al. The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nat. Immunol. 3451–456 (2002).
-
Dahan, R. et al. The therapeutic activity of agonist anti-CD40 human monoclonal antibodies requires selective engagement of the FcγR. cancer cell 29820–831 (2016).
-
Yu, X et al. Isotype switching converts anti-CD40 antagonism to agonism to trigger potent antitumor activity. cancer cell 37850–866.e7 (2020).
-
Ma, DY & Clark, EA The role of CD40 and CD154/CD40L in dendritic cells. Semin. Immunol. 21265–272 (2009).
-
Yu, X et al. TNF receptor agonists induce distinct receptor groups to mediate differential agonist activity. Common. Biol. 4772 (2021).
-
Chester, C., Sanmamed, MF, Wang, J. & Melero, I. Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results and future strategies. Blood 13149–57 (2018).
-
Chin, SM et al. Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. Nat. Common. 94679 (2018).
Google Scholar
-
Gong, J., Chehrazi-Raffle, A., Reddi, S., and Salgia, R. Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations . J. Immunother. Cancer 68 (2018).
Google Scholar
-
Paluch, C., Santos, AM, Anzilotti, C., Cornall, RJ & Davis, SJ Immune checkpoints as therapeutic targets in autoimmunity. Front. Immunol. 92306 (2018).
Google Scholar
-
Curnock, AP et al. Cell-targeted PD-1 agonists that mimic PD-L1 are potent T-cell inhibitors. JCI Overview 6e152468 (2021).
Google Scholar
-
Bryan, CM et al. Computational design of a synthetic PD-1 agonist. proc. Natl Acad. Know United States 118e2102164118 (2021).
-
Lee, JY et al. Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy. Nat. Common. 713354 (2016).
-
Bardhan, K. et al. PD-1-Y248 phosphorylation is a marker of PD-1-mediated inhibitory function in human T cells. Science. representing 917252 (2019).
Google Scholar
-
Chemnitz, JM, Parry, RV, Nichols, KE, June, CH & Riley, JL SHP-1 and SHP-2 associate with the immunoreceptor tyrosine-based switch pattern of programmed death 1 upon primary lymphocyte stimulation human T cells, but only receptor ligation prevents T cell activation. J. Immunol. 173945–954 (2004).
-
Patsoukis, N., Wang, Q., Strauss, L. & Boussiotis, VA Revisiting the PD-1 pathway. Science. Adv. 6eabd2712 (2020).
-
Jones, B., Tite, JP, and Janeway, CA Jr. Different phenotypic variants of A20/2J mouse B-cell tumor are selected for by antigen and mitogen-triggered cytotoxicity of L3T4-positive and restricted T-cell clones to AI. J. Immunol. 136348-356 (1986).
-
Lu, RM et al. Development of therapeutic antibodies for the treatment of diseases. J. Biomed. Science. 271 (2020).
-
Tabasinezhad, M. et al. Trends in affinity maturation of therapeutic antibodies: from in vitro sequencing approaches to next-generation approaches. Immunol. Lett. 212106-113 (2019).
-
Chodorge, M. et al. A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell death differs. 191187-1195 (2012).
-
Segal, NH et al. Phase I study of utomilumab monotherapy (PF-05082566), a 4-1BB/CD137 agonist, in patients with advanced cancer. Clin. Cancer Res. 241816–1823 (2018).
-
Rudnick, SI et al. Influence of antigen affinity and internalization on uptake and penetration of anti-HER2 antibodies in solid tumors. Cancer Res. 712250-2259 (2011).
-
Wajant, H. Principles of antibody-mediated TNF receptor activation. Cell death differs. 221727-1741 (2015).
-
Roghanian, A. et al. Human FcγRIIB (CD32B) antagonist antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo. cancer cell 27473–488 (2015).
-
Krissinel, E. Stock-based detection of oligomeric states of proteins in jsPISA. Nucleic Acids Res. 43W314–W319 (2015).
-
Krissinel, E. & Henrick, K. Inference of macromolecular assemblies from the crystalline state. J.Mol. Biol. 372774–797 (2007).
-
Davis, CB et al. Combination of a PD-1 antagonist and a 4-1BB agonist for the treatment of cancer. International patent publication number WO 2015/119923 A1 (2015).
-
Korman, AJ et al. Human monoclonal antibodies against programmed death 1 (PD-1) and methods of treating cancer using anti-PD01 antibodies alone or in combination with other immunotherapeutics. International patent publication number WO 2006/121168 A1 (2006).
-
Keller, T et al. Antibodies which bind to human CD27 and their uses. US Patent 9,169,325 (2015).
-
Hanke, T et al. Nucleic acids encoding anti-CD28 superagonist antibodies. US Patent 7,585,960 (2009).
-
Arakawa, F. et al. Cloning and sequencing of the VH and VK anti-CD3 monoclonal antibody genes, and construction of a mouse/human chimeric antibody. J. Biochem. 120657–662 (1996).
-
Meyer, L. et al. A simplified workflow for monoclonal antibody sequencing. PLOS ONE 14e0218717 (2019).
-
Sallusto, F. & Lanzavecchia, A. Efficient soluble antigen presentation by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1791109–1118 (1994).
-
Gate, D. et al. Clonal-expanding CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature 577399–404 (2020).
-
Fernandes, RA et al. Inhibition of immune receptors by forced recruitment of phosphatase. Nature 586779–784 (2020).
-
Austin, CD et al. Endocytosis and sorting of ErbB2 and the site of action of anticancer drugs trastuzumab and geldanamycin. Mol. Biol. Cell 155268–5282 (2004).
-
Sopp, JM et al. On-target IgG hexamerization driven by a C-terminal IgM tail piece fusion variant confers enhanced complement activation. Common. Biol. 41031 (2021).